This is only a partial list of the past faculty and honored guests that have participated in the Prague Summer Program.
| Charles Baxter | Willis Barnstone | Ann Beattie | Marvin Bell |
| Petr Bílek | Michael Blumenthal | Vance Bourjaily | Christopher Buckley |
| Andrei Codrescu | Michael Collier | Peter Cooley | Gerald Costanzo |
| Moira Crone | Barbara Cully | Aleš Debeljak | Alison Deming |
| Mark Doty | Slavenka Drakulić | Deborah Eisenberg | Nancy Eimers |
| Helen Epstein | Robert Eversz | Steve Feffer | Carolyn Forche |
| Helen Fremont | William Gass | Jaimy Gordon | Linda Gregerson |
| Donald Hall | Václav Havel | Robin Hemley | Edward Hirsch |
| Cynthia Hogue | Miroslav Holub | Garrett Hongo | Richard Jackson |
| Mark Jarman | Diane Johnson | Geronimo Johnson | Rodger Kamenetz |
| Mary Karr | Tracy Kidder | Galway Kinnell | Carolyn Kizer |
| Ivan Klíma | Eda Kriseová | Sydney Lea | Brad Leithauser |
| Philip Levine | Alan Levy | Margo Livsey | Bret Lott |
| Arnošt Lustig | Anne Marie Macari | Valerie Martin | William Matthews |
| Elizabeth McCracken | Colleen McElroy | William Meredith | Christopher Merrill |
| Mary Morris | Bharati Mukherjee | Carol Muske | Robert Olen Butler |
| Alicia Ostriker | Gregory Orr | Grace Paley | Joseph Parisi |
| Jiří Pehe | Iva Pekárková | Jayne Anne Phillips | Stanley Plumly |
| Melissa Pritchard | Francine Prose | Susan Richards-Shrive | Chuck Rosenthal |
| Tomaž Šalamun | Mary Jo Salter | Lynn Sharon Schwartz | Herbert Scott |
| Sandra Seaton | Maurya Simon | Josef Škvorecký | Mark Slouka |
| Carol Smith | Pavel Šrut | Maura Stanton | David St. John |
| Gerald Stern | Steven Stern | Jiri Stransky | Amy Tan |
| Ludvík Vaculík | Jean Valentine | Michael Waters | C.K. Williams |
| Gail Wronsky | Al Young | Adam Zagajewski | William Pitt Root |
| Pamela Uschuk | Joshua Mensch |